N-dihydrogalactochitosan reduces mortality in a lethal mouse model of SARS-CoV-2
Fig 4
N-dihydrogalactochitosan treated mice surviving SARS-CoV-2 inoculation produce neutralizing antibodies.
Neutralizing antibody was assessed by 80% plaque reduction neutralization test (PRNT80) in serum from hACE2 transgenic mice surviving to day 14 post inoculation. No PBS treated mice inoculated with 104 PFU SARS-CoV-2 were available for comparison due to uniform mortality. * p < 0.05, ** p < 0.01, LD = limit of detection. Kruskal-Wallis test with Dunn corrected multiple comparisons, H = 17.87, p = 0.0005, 3 degrees of freedom. Symbols are individual animals, horizontal lines are geometric mean and error bars show geometric standard deviation, n = 2–12 per group, two combined experiments.