N-dihydrogalactochitosan reduces mortality in a lethal mouse model of SARS-CoV-2
Fig 1
N-dihydrogalactochitosan protects mice from SARS-CoV-2 mortality.
(a) Experimental design where 6-week-old male and female hACE2 transgenic mice were treated with 0.75% GC or PBS delivery vehicle at days -3, -1 and +1 post-inoculation. Mice were inoculated at day 0 with 103 or 104 PFU of SARS-CoV-2 or PBS (mock). Animals were weighed daily, and throats were swabbed on days 1 through 3. (b) Weight represented as a percentage of individual mouse weight at the time of inoculation. A main effect only model two-way ANOVA with Tukey corrected multiple comparisons yielded an F = 52.80, p<0.0001, 4 degrees of freedom. Each symbol represents an individual mouse, and the horizontal lines show geometric mean and error bars are geometric standard deviation. (c) Survival proportions. The solid lines are survival proportions, and the shaded boxes show 95% confidence intervals. (d) Logrank Mantel-Cox comparisons of survival proportions with Bonferroni corrected p-values, multiple pairwise tests, 1 degree of freedom. n = 8–16 per group, 2 combined experiments.