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Glioma-derived exosomes drive the differentiation of neural stem cells to astrocytes

Fig 6

Immunocytochemistry of differentiated NSCs after 10 days showing many astrocytes expressed glioma feature.

NPCs were maintained under ODC differentiation medium and treated with (A) exosome I and (B) exosome II. After 10 days in culture, cells were immunostained to reveal the co-expression of GFAP (red) and CD133 (green) (C). DAPI was used to stain nuclei (blue). Scale bar 200 μm (A and B) and 100 μm (C). (D) Cell count analysis of GFAP and CD133 expressing cells. Data represent mean ± SD.

Fig 6

doi: https://doi.org/10.1371/journal.pone.0234614.g006