Discovery of antitumor lectins from rainforest tree root transcriptomes
(A) Schematic representation of the ML6 sequence (top) with unique instances of mannose-binding domains identified (bottom, red). (B) Predicted computational structure of ML6 using the SWISS model (bacteriocin LlpA reference) viewed from the front (left) and side (right). (C) Top-down view of ML6 emphasizing the central “C” cup. Mannose-binding domains are highlighted yellow. (D) Circular dichroism spectrum of recombinant ML6 protein.