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The expression patterns of immune response genes in the Peripheral Blood Mononuclear cells of pregnant women presenting with subclinical or clinical HEV infection are different and trimester-dependent: A whole transcriptome analysis

Fig 8

Changes in gene expression and biologic pathways affected following subclinical or acute HEV infection in the pregnant women in 2nd trimester with reference to pregnant controls from corresponding trimesters.

Differential expression analysis in PBMCs from pregnant subclinical (PR-2-SC) and acute (PR-2-acute) patients as compared to respective healthy pregnant controls. (A) DAVID was used to identify over-represented Gene Ontology (GO) terms. Significant enriched GO terms of differentially expressed up-regulated genes in PR-2-SC and PR-2-acute patients. The vertical axis is the GO category and the horizontal axis is–log P value <0.05. (B)The enriched KEGG pathways of differentially expressed up-regulated genes in PR-2-SC and PR-2-acute patients (P value <0.05).(P value is modified Fisher’s Exact test P- value or EASE score).

Fig 8

doi: https://doi.org/10.1371/journal.pone.0228068.g008