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The expression patterns of immune response genes in the Peripheral Blood Mononuclear cells of pregnant women presenting with subclinical or clinical HEV infection are different and trimester-dependent: A whole transcriptome analysis

Fig 7

Changes in gene expression and biologic pathways affected following subclinical or acute HEV infection in the pregnant women in 3rd trimester with reference to non-pregnant controls.

Differential expression analysis in PBMCs from pregnant subclinical (PR-3-SC) and acute (PR-3-acute) patients as compared to healthy non-pregnant controls (NPR-control). (A) DAVID was used to identify over-represented Gene Ontology (GO) terms. Significant enriched GO terms of differentially expressed up-regulated genes in PR-3-SC and PR-3-acute patients. The vertical axis is the GO category and the horizontal axis is–log P value <0.05.(B)The enriched KEGG pathways of differentially expressed up-regulated genes in PR-3-SC and PR-3-acute patients (P value <0.05).(P value is modified Fisher’s Exact test P- value or EASE score).

Fig 7

doi: https://doi.org/10.1371/journal.pone.0228068.g007