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Preclinical evaluation of AT-527, a novel guanosine nucleotide prodrug with potent, pan-genotypic activity against hepatitis C virus

Fig 7

Mean profiles of AT-511 and its metabolites in monkey plasma over 72 h.

Cynomolgus monkeys (groups of 3 males per dose) were administered a single oral dose of AT-527 at (A) 30 mg/kg, (B) 100 mg/kg and (C) 300 mg/kg, and plasma concentrations of AT-511, AT-273, M1 and M4 were measured by LC-MS/MS. Data are mean ± SD for each group.

Fig 7