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Preclinical evaluation of AT-527, a novel guanosine nucleotide prodrug with potent, pan-genotypic activity against hepatitis C virus

Fig 6

Mean profiles of AT-511 and its metabolites in rat plasma over 24 h.

Sprague-Dawley rats (3 male and 3 female) were administered a 300 mg/kg single oral dose of AT-527 and plasma concentrations of AT-511, AT-273, M1 and M4 were measured by LC-MS/MS. Data are mean ± SD of all 6 animals.

Fig 6

doi: https://doi.org/10.1371/journal.pone.0227104.g006