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Profusion of G-quadruplexes on both subunits of metazoan ribosomes

Fig 1

Secondary structures of the LSU and SSU rRNAs of Homo sapiens.

(a) Nucleotide level solvent-Accessible Surface Area of the human LSU and SSU determined from intact ribosomes (PDB ID: 4UG0 [36]). (b) G-quadruplex forming sequences identified by the 3 x 4 motif are highlighted in red and those identified with the 2 x 4 motif are highlighted in blue. Only G-quadruplex forming sequences located on the ribosomal surface are shown. These images were generated with RiboVision [37].

Fig 1