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A computational strategy for finding novel targets and therapeutic compounds for opioid dependence

Table 1

Significantly enriched biological processes and pathways induced by morphine which were involved in opioid-mediated pain pathways and corresponding literature support.

In the “Phase” column, Up-IE, Up-M, and Up-L represent upregulated in the IE, M, and L phase, respectively, while that Down-IE, Down-M, and Down-L represent downregulated in the IE, M, and L phase, respectively.

Table 1

doi: https://doi.org/10.1371/journal.pone.0207027.t001