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Chronic oral application of a periodontal pathogen results in brain inflammation, neurodegeneration and amyloid beta production in wild type mice

Fig 2

Pg/gingipain signals are detected peri- and intra-nuclearly by confocal microscopy.

(A) CA1 region in 3-D. (B) Orthogonal analysis of 3-D image shown in A. Orthogonal projections a (green rectangle) and b (red rectangle) are side views of serial confocal sections of the same area. These images show intra-nuclear presence of Pg/gingipain.

Fig 2

doi: https://doi.org/10.1371/journal.pone.0204941.g002