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Role of extracellular matrix and microenvironment in regulation of tumor growth and LAR-mediated invasion in glioblastoma

Fig 10

Effect of CSPGs on the spatial dynamics of populations of microglia and astrocytes, and LAR-CSGAG binding.

(A) Population of invasive (activated) astrocytes for various CSPG levels (1.0 × 10−4, 1.0 × 10−3, 25, 125, 250 μg/mL). (B) Normalized populations of ramified (blue) and activated (yellow) microglia for various CSPG levels (2.5 × 10−2, 25, 125, 250 μg/mL). (C) Normalized population of tumor cells for various CSPG levels (2.5 × 10−2, 2.5, 250 μg/mL). (D,E) Distributions of tumor cells (green star ) and [LAR]-[CSGAG] complex (red star ) in response to low (2.5 × 10−2 μg/mL) and high (250 μg/mL) CSPGs. (F) Concentrations of [LAR] (blue) and [LAR]-[CSGAG] (yellow) for various CSPG levels (2.5 × 10−2, 2.5 × 10−1, 2.5, 250 μg/mL). Domain size = [70, 130]2.

Fig 10

doi: https://doi.org/10.1371/journal.pone.0204865.g010