Role of extracellular matrix and microenvironment in regulation of tumor growth and LAR-mediated invasion in glioblastoma
(A) Time courses of concentrations of LAR ([R], solid) and CS-GAGA-LAR complex ([E.R], dotted) in response to high (E = 100 μg/ml) and low (E = 0.1 μg/ml) CSPG stimuli. (B) CSPG binding response. (C,D) Time courses of CSGAG-LAR binding activity (D) for various binding ratios in response to fluctuating CSPG input values in (C): (E(t) = 50*cos(πt/24) + 50) in the range of 0-100 μg/ml. (E,F) Time courses of unbinding strength ζi for various Hill coefficients, m1 = 1, 2(base), 10 in (E) and KER = 0.005, 0.5, 5 in (F), in response to the fluctuating CSPG levels E(t) = 5*cos(πt/24) + 5. Initial condition: . Other parameters as in Table 3.