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Role of extracellular matrix and microenvironment in regulation of tumor growth and LAR-mediated invasion in glioblastoma

Fig 6

Effect of the inhibition strength β on the cell cycle regulation in response to glucose fluctuation.

(A,B) Time courses of variables in cell cycle (CycB, Cdh1, p55cdcT, p55cdcA, plk1, volume, and masss) and miR-451-AMPK-mTOR module in response to a periodically fluctuating glucose level (0.45*cos(π*t/20) + 0.5) when β = 0.07 (low), 2.0 (high). When β is decreased (β = β* → 0.07 in (A)) or increased (β = β* → 2.0 in (C)) from the base value (β* = 1.0), the system leads to G0-dominant and full cell cycle system, respectively. (C) Distribution of normal cell cycles and quiescent phase for various β’s (β = 0.07, 1.0, 2.0). As β is increased, average duration of G0-phase (red bar) is decreased and the total number of normal cell cycles (black circle) is increased. (D) Characterization of normal cell cycle and quiescent mode in the τcycτG0 plane in response to increase or decrease in β.

Fig 6

doi: https://doi.org/10.1371/journal.pone.0204865.g006