Role of extracellular matrix and microenvironment in regulation of tumor growth and LAR-mediated invasion in glioblastoma
(A,B) Time courses of variables in cell cycle (CycB, Cdh1, p55cdcT, p55cdcA, plk1, volume, and masss) and miR-451-AMPK-mTOR module in response to a periodically fluctuating glucose level (0.45*cos(π*t/20) + 0.5) when β = 0.07 (low), 2.0 (high). When β is decreased (β = β* → 0.07 in (A)) or increased (β = β* → 2.0 in (C)) from the base value (β* = 1.0), the system leads to G0-dominant and full cell cycle system, respectively. (C) Distribution of normal cell cycles and quiescent phase for various β’s (β = 0.07, 1.0, 2.0). As β is increased, average duration of G0-phase (red bar) is decreased and the total number of normal cell cycles (black circle) is increased. (D) Characterization of normal cell cycle and quiescent mode in the τcyc − τG0 plane in response to increase or decrease in β.