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Role of extracellular matrix and microenvironment in regulation of tumor growth and LAR-mediated invasion in glioblastoma

Fig 4

Effect of hypoxia on the dynamics of intracellular signaling pathways.

Time courses of cell cycle variables (CycB, Cdh1, p55cdcT, p55cdcA, plk1, mass, and masss) and miR-451-AMPK-mTOR module in response to high and low glucose levels in normoxia (A) and reduced oxygen (B) conditions. Under a normoxia condition, the cell enters the quiescent phase (G0-phase; [G0] = 1) when glucose is deprived around t = 300 h. However, the cell returns to the normal active cell cycle when the glucose level is increased to the high level around t = 500 h. Under a hypoxic condition, the system leads to a slower cell cycle.

Fig 4

doi: https://doi.org/10.1371/journal.pone.0204865.g004