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The vacuolar-type ATPase inhibitor archazolid increases tumor cell adhesion to endothelial cells by accumulating extracellular collagen

Fig 1

Treatment of HUVECs with archazolid for 24 h does not evoke cytotoxic effects.

Confluent HUVECs were treated either with archazolid (arch) or DMSO (co) for 24 h and 48 h. Both the metabolic activity (A) and the release of LDH (B) were determined. Treatment with lysis buffer served as positive control for LDH release. (A, B) Data are expressed as mean ± SEM (n = 3). *p ≤ 0.05 versus DMSO control.

Fig 1

doi: https://doi.org/10.1371/journal.pone.0203053.g001