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Oral edible plant vaccine containing hypoallergen of American cockroach major allergen Per a 2 prevents roach-allergic asthma in a murine model

Fig 6

Cytokine mRNA levels of splenocytes from each group of mice by real-time PCR.

(A) IL-4, (B) IL-13, (C) IL-6, (D) IL-10, (E) Interferon γ (IFN-γ), and (F) TNF-α. Data are expressed as mean of increasing fold ±SEM (n = 5–6 per group). The statistical significance of differences among groups was assessed by the Dunnett’s test. * denoted p<0.05; **p<0.01; ***p<0.001.

Fig 6

doi: https://doi.org/10.1371/journal.pone.0201281.g006