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Oral edible plant vaccine containing hypoallergen of American cockroach major allergen Per a 2 prevents roach-allergic asthma in a murine model

Fig 4

Specific antibody levels in Per a 2 sensitized mice.

(A) Per a 2-specific IgE antibodies in the sera at the indicated weeks. (B) Serum levels of Per a 2-specific IgE, IgG 1 and IgG2a among groups at week 9 determined by ELISA. Results are mean±SEM of 5–6 mice from each group. *p<0.05; ***p<0.001 by one-way analysis of variance with the Bonferroni multiple range test.

Fig 4

doi: https://doi.org/10.1371/journal.pone.0201281.g004