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Construction of an integrated database for hERG blocking small molecules

Fig 8

Box plot of IC50 distribution about each Murcko framework.

(a) IC50 values for 82 Murcko frameworks containing more than 10 compounds sorted by the IC50 values of the most potent inhibitors. (b) Corresponding IC50 values reported before 2009. The horizontal axes of both plots represent each of the 82 Murcko frameworks.

Fig 8

doi: https://doi.org/10.1371/journal.pone.0199348.g008