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Reduction in terminally differentiated T cells in virologically controlled HIV-infected aging patients on long-term antiretroviral therapy

Fig 1

Distribution of CD4+ and CD8+ T cell subsets in HIV-infected patients with controlled viremia on long-term antiretroviral therapy (ART).

(A) Lymphocyte distribution measured as frequencies of CD4+, CD8+, and non-T cell populations in HIV-infected patients (HIV+) and uninfected controls (UNC). (B) Frequencies of CD8+ T cells by increasing CD4 T cell counts in HIV+ and UNC. Frequencies of CD4+ (C) and CD8+ (D) T cell subsets defined as naïve (N, CD28IntCD95LoCD45RAHiCCR7Hi), central memory (CM, CD28HiCD95HiCD45RALoCCR7Hi) and effector memory (EM, CD28LoCD95HiCCR7Lo). (n = 100 HIV+, n = 75 UNC) (*p<0.05, **p<0.01, ***p<0.001, ****p<0.0001).

Fig 1