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SeedVicious: Analysis of microRNA target and near-target sites

Fig 2

Multiple uses of seedVicious.

A) Cumulative distribution of the number of transcripts with at least two target sites with respect to the minimum distance between pairs of targets. The graph compares the distribution of all transcript (black), transcript/microRNA pairs with experimentally validated interactions (blue) and those with strongly validated interactions (red) according to miRTarBase. B) Precision of microRNA target prediction for different cut-offs of minimum distance between pairs of targets. The peak corresponds to a distance of 6, that is, two contiguous target sites. C) Precision of microRNA target prediction for multiple targets sites for the same microRNA. D) Evolutionary turnover of microRNA canonical target sites for let-7 in lin-14 in roundworm species using maximum parsimony.

Fig 2

doi: https://doi.org/10.1371/journal.pone.0195532.g002