Advertisement
Browse Subject Areas
?

Click through the PLOS taxonomy to find articles in your field.

For more information about PLOS Subject Areas, click here.

< Back to Article

Testing therapeutics in cell-based assays: Factors that influence the apparent potency of drugs

Fig 5

Impact of exposure time and virus input on efficacy of toremifene citrate.

(A) Huh 7 cells were infected at an MOI of 1, and antiviral activity of toremifene citrate was evaluated at indicated time points. (B) Huh 7 cells were infected at indicated MOIs and antiviral activity of toremifene citrate was evaluated at 72 hpi. (C, D) EC50s with corresponding assay endpoints or MOIs are shown for comparison. The experiment was performed twice using the fluorescent assay. Representative graphs are shown. Abbreviations:EC50, half maximal effective concentration; hpi, hours post-inoculation; MOI, multiplicity of infection.

Fig 5

doi: https://doi.org/10.1371/journal.pone.0194880.g005