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A bi-stable feedback loop between GDNF, EGR1, and ERα contribute to endocrine resistant breast cancer

Fig 6

Tamoxifen resistant MCF-7 cells are biased for signatures associated with GDNF activation.

(A) Scores summarizing the expression similarities between TamS (black) and TamR (red) cells to gene expression targets that lie downstream of either ERα or GDNF.

Fig 6