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A bi-stable feedback loop between GDNF, EGR1, and ERα contribute to endocrine resistant breast cancer

Fig 3

GDNF stimulates the rate at which paused Pol II transitions into productive elongation.

(A) Heatmap depicting changes in RNA polymerase density following 1 hour of GDNF treatment in B7TamS MCF-7 cells. (B) Changes in pausing index between treated (1 hour) and untreated TamS MCF-7 cells at the indicated class of genes. The Y-axis represents log base e of changes in read density in the promoter compared to the gene body.

Fig 3