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A bi-stable feedback loop between GDNF, EGR1, and ERα contribute to endocrine resistant breast cancer

Fig 1

GDNF activates thousands of target genes.

(A) Schematic illustration of experimental setup. PRO-seq libraries were prepared from TamS and TamR MCF-7 clones grown in the presence of GDNF for 0, 1, or 24 hours. (B-C) MA plot shows significantly upregulated and downregulated genes (red) following 1 hour (B) or 24 hours (C) of GDNF treatment in TamS MCF-7 cells.

Fig 1