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DIVA metabolomics: Differentiating vaccination status following viral challenge using metabolomic profiles

Fig 4

S-plots of supervised OPLS-DA analysis of RP-UPLC-MS profiled plasma metabolites from vaccinated and non-vaccinated calves following BPI3V challenge.

Supervised OPLS-DA S-plot plots of plasma metabolite profiles from vaccinated and non-vaccinated calves at days 2, 6, 14 and 20 p.i. are illustrated in figures A-D respectively. The location of AMRTPs on the S-Plot is a combination of influence (p [1]) and reliability p(corr) [1] on the discrimination of study groups by OPLS-DA. Selected and identified vaccine response markers and AMRPTs selected are indicated on the S-Plot.

Fig 4