DIVA metabolomics: Differentiating vaccination status following viral challenge using metabolomic profiles
Supervised OPLS-DA S-plot plots of plasma metabolite profiles from vaccinated and non-vaccinated calves at days 2, 6, 14 and 20 p.i. are illustrated in figures A-D respectively. The location of AMRTPs on the S-Plot is a combination of influence (p ) and reliability p(corr)  on the discrimination of study groups by OPLS-DA. Selected and identified vaccine response markers and AMRPTs selected are indicated on the S-Plot.