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Combined use of protein biomarkers and network analysis unveils deregulated regulatory circuits in Duchenne muscular dystrophy

Fig 2

Signature-based classification of affected vs. control subjects for each individual.

(A) Heatmap of the six proteins included in the biomarker panel (columns) across the 70 subjects (rows). Control subjects: top 28 rows; affected subjects: bottom 52 rows. (B) Signatures composed of at least two proteins (red boxes) out of six are needed to accurately classify each subject as being a member of either the control or the affected group. (C) The heatmap of the distance matrix shows that signatures of length two are actually sufficient to correctly divide subjects into two groups. (D) A map of the subjects based on the distance matrix confirms that the two emerging groups are of homogeneous composition and points to a possible subgroup of affected individuals (green: control subjects, red: affected subjects; colors were added after the map was drawn).

Fig 2

doi: https://doi.org/10.1371/journal.pone.0194225.g002