Regulation of influenza virus replication by Wnt/β-catenin signaling
C57BL/6J mice were treated with iCRT14 (50 mg/kg) or vehicle control daily from one day prior to infection until day 6 post-infection. The mice were challenged with influenza virus A/PR/8/34 (1,000 pfu/mouse). (A) Percent of body weight loss. Body weight loss is presented as the mean ± SE. *p < 0.05 vs. vehicle control at day 8 (Two-way ANOVA followed by post-hoc sidak test). (B, C) Kaplan–Meier survival curves and mean day of survival of mice in the iCRT14 and vehicle control groups. The Mantel-Cox χ2 test and Student’s t-test were used for survival curves and mean day of survival, respectively. *p< 0.05 vs. control group; **p<0.01 v.s control group, n = 12–13 animals per group.