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Regulation of influenza virus replication by Wnt/β-catenin signaling

Fig 5

Effects of iCRT14 on influenza virus-induced IFN response and iCRT14-mediated inhibition of influenza virus RNA synthesis in Vero cells.

(A, B) A549 cells were infected with A/PR/8/34 at an MOI of 1 for various times. The cells were treated with iCRT14 (12.5 μM) or vehicle control 1 h prior to infection. IFN α1 and β1 mRNA levels were determined by real-time PCR and normalized to GAPDH. The data are expressed as fold change relative to mock infection. (C) Vero cells were infected with A/PR/8/34 at an MOI of 5. The cells were treated with iCRT14 (12.5 μM) or vehicle control 1 h prior to infection. The cRNA, vRNA and mRNA levels of the NP gene were determined at 5 h post-infection using real-time PCR and normalized to GAPDH. The data are expressed as relative expression. The results of 3 independent experiments are presented as the mean ± SE. *p<0.05 vs. vehicle control, *p<0.01 vs. vehicle control (Student’s t-test).

Fig 5

doi: https://doi.org/10.1371/journal.pone.0191010.g005