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Spectrum of pathogen- and model-specific histopathologies in mouse models of acute pneumonia

Fig 8

Influenza A virus.

(A–F) After transnasal infection, IAV (100 PFU/ mouse) resulted in diffuse (A), necrotizing (B), bronchointerstitial pneumonia (B, C) with marked necrosis and sloughing of bronchial epithelial cells (C, arrowhead), lympho-histiocytic intraalveolar and interalveolar interstitial infiltration (D), prominent perivascular cuffing of lymphocytes (E) and protein-rich alveolar edema (F, asterisk). (A–F) Representative images are shown. Bar (A), 1 mm; (B—D, F), 20 μm; (E), 50 μm.

Fig 8

doi: https://doi.org/10.1371/journal.pone.0188251.g008