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Spectrum of pathogen- and model-specific histopathologies in mouse models of acute pneumonia

Fig 7

MERS-coronavirus.

(A—F) Transnasal infection with MERS-CoV (7 x 104 TCID50/ mouse) resulted in expansive (A), necrotizing, mixed-cellular bronchointerstitial pneumonia (B) with peribronchial and perivascular infiltration of lymphocytes (C, D), marked fibrinoid degeneration of blood vessels (D, asterisk), alveolar edema (E, arrowhead) and hemorrhage (F, arrowhead). (A–F) Representative images are shown. Bar (A), 1 mm; (B, C, E, F), 20 μm; (D), 50 μm.

Fig 7

doi: https://doi.org/10.1371/journal.pone.0188251.g007