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Spectrum of pathogen- and model-specific histopathologies in mouse models of acute pneumonia

Fig 5

Infection with L. pneumophila.

(A—D) At 48 hours and 6 days post transnasal infection with L. pneumophila (1 x 106 CFU/mouse), mice developed non-expansive (A), necrotizing to histiocytic interstitial pneumonia (B) with granuloma formation around blood vessels (C, arrowhead) and prominent lymphocytic perivascular cuffing with highly activated endothelial cells (D, arrowhead) at the 6 day-time point. (A—D) Representative images are shown. Bar (A), 1 mm; (B—D), 20 μm.

Fig 5

doi: https://doi.org/10.1371/journal.pone.0188251.g005