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Spectrum of pathogen- and model-specific histopathologies in mouse models of acute pneumonia

Fig 2

Infection with S. aureus.

(A—F) Transnasal infection of mice with S. aureus (5 x 107 CFU/ mouse) resulted in non-expansive (A), suppurative (B, C) to necrotizing (D) bronchopneumonia with infiltration of neutrophils and lymphocytes into perivascular spaces (E) and protein-rich alveolar edema (F, asterisk). (A–F) Representative images are shown. Bars (A), 1 mm; (C, D, F), 20 μm; (B, E), 50 μm.

Fig 2

doi: https://doi.org/10.1371/journal.pone.0188251.g002