Differences in the population structure of Neisseria meningitidis in two Australian states: Victoria and Western Australia
Distribution of NHBA peptides identified in VIC (panel A) and WA (panel B) during 2008–2012. The dendrogram represents a maximum likelihood tree (1000 bootstraps) generated using the peptide sequences of the 24 NHBA variants identified in the collection. The distribution of the NHBA peptides is represented in the adjoining bar charts which are coloured by clonal complexes. The NHBA-2 peptide found at the top of the tree is the variant incorporated in the Bexsero® vaccine. The dendrogram is drawn to scale, with the sum of the branch lengths between two peptides representing the proportion of amino acid differences between those peptides within the pairwise alignment.