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Mitochondrial dysfunction in the gastrointestinal mucosa of children with autism: A blinded case-control study

Fig 6

Synthesis of findings of the study.

Dysbiotic bacteria in the gastrointestinal tract of individuals with autism produce butyrate that drives the mitochondria to become overactive and very sensitive to oxidative stress. Xenobiotic agents (see previous review [35]) can increase oxidative stress through inflammation or by their intrinsic nature. This results in mitochondrial dysfunction that can contribute to gastrointestinal symptoms such as dysmotility (arrow symbol from mitochondrial dysfunction to colon).

Fig 6

doi: https://doi.org/10.1371/journal.pone.0186377.g006