Solution conformations of Zika NS2B-NS3pro and its inhibition by natural products from edible plants
(A) Chemical structures of six natural products identified to inhibit Zika NS2B-NS3pro. (B) Chemical structures of three natural products identified to have no detectable inhibitory activity on Zika NS2B-NS3pro. (C) Lineweaver-Burk plots for determining inhibitory constants (Ki) of six natural products on Zika NS2B-NS3pro. [S] is the substrate concentration; v is the initial reaction rate. The curves were generated by the program GraphPad Prism 7.0. The red circles are used to indicate that the inhibition is non-competitive, characteristic of the same Km but varying Vmax values in the presence of inhibitors at different concentrations.