Genome-wide association analysis identifies genetic correlates of immune infiltrates in solid tumors
(A-B) Relationship of CDKN2A copy number estimates to B and T cell estimates across TCGA melanoma. The horizontal scale is the log2 GISTIC CNA estimate (0 = diploid, -1.3 = homozygous loss). The signature scores are measured in units of standard deviation of the signature's variation across TCGA tumors. Independent tests of association were performed for CNA > -0.1 and CNA < 0.1. The lines drawn are the linear regressions of the gain/loss CNA with the immune estimate, with shading to indicate the 95% confidence interval around the line's slope (without model covariate adjustments or multiple test corrections). (C) Relationship of TP53 mutation to regulatory T cell (Treg) estimates across breast cancer. (D) Relationship of TP53 mutation to CD8+ Tcell estimates in head and neck cancer.