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Lung epithelial cells have virus-specific and shared gene expression responses to infection by diverse respiratory viruses

Fig 3

Patterns of gene expression changes mediated by viral infection.

(A) Genes differentially expressed in at least one viral infection at 24 h are plotted as log2-fold change with each virus along a different axis. Signature genes, which have significantly larger effects in one virus compared to all other treatments, are colored: blue = PR8, red = RV, yellow = MHV. (B) The number of genes uniquely up- or down- regulated by each virus or pairs of viruses. The numbers along the center diagonal are the signature genes with boxes colored as in (A). The off-diagonal numbers are genes that have differential expression in two viruses compared to mock and the third virus, but are not significantly different from each other.

Fig 3

doi: https://doi.org/10.1371/journal.pone.0178408.g003