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Epidermal loss of Gαq confers a migratory and differentiation defect in keratinocytes

Fig 1

Mice with epidermal loss of Gαq do not demonstrate phenotypic defects under normal conditions.

A) Schematic representation of the animal model used to derive a delete Gnaq exon 6 (Ex6) from the basal epidermal compartment concomitant with global deletion of Gna11. B) Representative pictures of Gα11KO/Gαq-WT control and Gα11KO/Gαq-eKO mice. C) Western blot demonstrating Gαq deletion in the epidermal keratinocytes but not fibroblasts after expression of K14-Cre. D) Normal skin samples from Gα11KO/Gαq-WT control and Gα11KO/Gαq-eKO animals (N = 4 each) were examined for histology (H&E), proliferation (Ki67), and differentiation (K10).

Fig 1