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Piphillin: Improved Prediction of Metagenomic Content by Direct Inference from Human Microbiomes

Fig 1

Piphillin algorithm.

The representative sequence of each OTU in the sample is first searched against 16S rRNA sequences in the genome database to obtain inferred genome(s). Then the OTU abundance table is converted to a genome abundance table. The resulting table is normalized by the 16S rRNA copy number of each genome and a metagenome is inferred using the gene contents (copy number of each gene) of each genome in the database.

Fig 1