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A High-Throughput Screen Identifies 2,9-Diazaspiro[5.5]Undecanes as Inducers of the Endoplasmic Reticulum Stress Response with Cytotoxic Activity in 3D Glioma Cell Models

Fig 8

Compound 8 and 6 synergize to reduce the viability of patient-derived glioma cell lines.

Combination (6 x 6) response profiles for compound 8, 6, and 3 in JHH-136 (A) and JHH-520 (B) cells. Each response profile is displayed as heatmaps of cell viability (percent response normalized to thapsigargin control; left panels) and DBSumNeg analysis (right panels).

Fig 8

doi: https://doi.org/10.1371/journal.pone.0161486.g008