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A High-Throughput Screen Identifies 2,9-Diazaspiro[5.5]Undecanes as Inducers of the Endoplasmic Reticulum Stress Response with Cytotoxic Activity in 3D Glioma Cell Models

Fig 6

Compound 8 induces cell death in U87-MG spheroids.

U87-MG spheroids were treated for 48 h with either compound 8 or inactive analog 8e at the indicated concentrations. Spheroids were stained with Hoechst (blue) and propidium iodide (red) to mark nuclei and dead cells, respectively. For each spheroid, one single Zā€™ plane is shown.

Fig 6

doi: https://doi.org/10.1371/journal.pone.0161486.g006