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A High-Throughput Screen Identifies 2,9-Diazaspiro[5.5]Undecanes as Inducers of the Endoplasmic Reticulum Stress Response with Cytotoxic Activity in 3D Glioma Cell Models

Fig 1

Schematic workflow for compound screening and triage.

qHTS indicates assays performed in 1,536- and 384-well format. AC50 obtained in qHTS assays are summarized in Fig 2. Results of remaining low-throughput assays are summarized in Fig 3.

Fig 1

doi: https://doi.org/10.1371/journal.pone.0161486.g001