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Nonlinear Dynamics in Gene Regulation Promote Robustness and Evolvability of Gene Expression Levels

Fig 5

Nonlinearity creates regions presenting sudden changes in phenotype with small changes in genotype.

Expression level as a function of the composite parameters α and K for the G-P mappings of circuit I obtained with N = 1 (panel a) and N = 2 (panel b). The product, (E × R), of evolvability computed for large scale perturbations (1-mutant neighbors) and sensitivity-based robustness is color-coded, with blue indicating a negative E/R correlation and red indicating the region of high robustness and evolvability (cf. Figure B in S1 File).

Fig 5