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Nonlinear Dynamics in Gene Regulation Promote Robustness and Evolvability of Gene Expression Levels

Fig 4

Nonlinearity shapes robustness-evolvability correlations.

The G-P mapping of circuit I for different values of N. The first column (a,d,g) shows the relationship between scaled intrinsic noise and sensitivity-based robustness; the second column (b,e,h) shows sensitivity-based robustness versus evolvability, when evolvability is computed using large-scale parameter perturbations (1-mutant neighbors); the third column (c,f,i) shows robustness against evolvability when both are computed using 10% parameter perturbations. The Pearson correlation coefficient r is displayed in the panel titles. Colors indicate genotype density in each plot (cf. Figure I in S1 File for the equivalent analysis for circuit II).

Fig 4