Altered Lipid Composition of Surfactant and Lung Tissue in Murine Experimental Malaria-Associated Acute Respiratory Distress Syndrome
C57BL/6J mice were injected intraperitoneally with 104 erythrocytes infected with Plasmodium berghei (PbNK65) or P. chabaudi AS (PcAS). Peripheral parasitemia (panel A) and weights of the left lungs (panel B) were determined at day 6, 8 and 10 post infection (n = 6–8 mice for each time point and strain). (panel C) Representative pictures of right lungs (not perfused) from uninfected (CTR) or infected mice (day 10 post infection). (panel D) Hz content in lung tissue (pmole Hz /mg lung tissue) at day 10 post infection. *p<0.05; **p<0.01; *** p<0.0001 vs CTR; °°°p< 0.01 PbNK65 vs PcAS.(n = 6–8 mice for each time point and strain).