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Transcriptomic Analysis of Induced Pluripotent Stem Cells Derived from Patients with Bipolar Disorder from an Old Order Amish Pedigree

Fig 1

Selection of fibroblasts from the NIGMH repository for generation of iPSCs.

Fibroblasts from patients diagnosed with Type I BPD and their sibling controls of Old Order Amish pedigree were obtained from the NIGMS Human Genetic Cell Repository at Coriell Institute for Medical Research for reprogramming into iPSCs using the Sendai virus method. The pedigree has been updated according to DSM-IV. Circles and squares represent females and males, respectively. MDD = Major Depressive Disorder; Atyp. BP:NOS = Atypical Bipolar (not otherwise specified). Other diagnosis for the patient from which ABP12 was derived was post-partum depression.

Fig 1