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Heterodimerization of Two Pathological Mutants Enhances the Activity of Human Phosphomannomutase2

Fig 10

F119L/R141H structural model.

The two chains are represented as cartoons in light or dark grey. F119 on one chain and L119 on the other chain, are shown as spheres in green or red respectively. R141on one chain and H141 on the other chain, are shown as sticks in green or red respectively. The side chains of E93 and R116 forming a salt bridge at the interface, are shown as sticks in orange or blue respectively. The side chains of K115 and N101 forming a H-bond at the interface, are shown as sticks cyan or magenta respectively.

Fig 10

doi: https://doi.org/10.1371/journal.pone.0139882.g010