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Likelihood of Null Effects of Large NHLBI Clinical Trials Has Increased over Time

Fig 1

Relative risk of showing benefit or harm of treatment by year of publication for large NHLBI trials on pharmaceutical and dietary supplement interventions.

Positive trials are indicated by the plus signs while trials showing harm are indicated by a diagonal line within a circle. Prior to 2000 when trials were not registered in clinical trials.gov, there was substantial variability in outcome. Following the imposition of the requirement that trials preregister in clinical trials.gov the relative risk on primary outcomes showed considerably less variability around 1.0.

Fig 1

doi: https://doi.org/10.1371/journal.pone.0132382.g001