Human Adipose Tissue-Derived Mesenchymal Stem Cells Target Brain Tumor-Initiating Cells
(A) The migration ability of hAT-MSCs was assessed and compared with that of HFF1 cells. Representative images of stained filters show migrated hAT-MSCs toward medulloblastoma-BTICs, atypical teratoid/rhabdoid tumors (AT/RT)-BTICs and glioblastoma-BTICs. hAT-MSCs exhibited greater migratory abilities toward BTICs compared with HFF1 cells and hAT-MSCs did not migrate toward HFF1; ×40 magnification. (B) Migration was quantified based on the OD value after dissolving the stained cells. The data shown are averages of quadruplicate wells, and bars represent ± SD. ***Significant difference from control (P < 0.001).